Effects of high-frequency repetitive transcranial magnetic stimulation on clinical outcomes and brain function in patients with chronic low back pain

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300075557

Enrollment

Unknown

Registered

2023-09-08

Start date

2023-09-10

Completion date

Unknown

Last updated

2023-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic low back pain

Interventions

rTMS group:In addition to routine treatment for low back pain (including bed rest at the acute phase, medication, traditional Chinese medicine treatment, physical therapy, manual therapy, exercise the

Stimulation frequency: 10Hz

Each series of stimuli has a duration of 10 seconds and an interval of 20 seconds

Stimulation pulse count: 1500 times/day

Treatment duration: 7.5min/day

Treatment frequency: 5 times/week at the first 6 weeks

2 times/week at the latter 6 weeks. Total intervention period is 12 weeks.

sham-rTMS group:In addition to routine treatment for low back pain, the sham high-frequency rTMS treatment is also received. Pseudo stimulus coils will be used, and other parameters are the same with

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ? aged from 18-65 years old ? MMSE = 17 ? Right-handedness which was determined by the Edinburgh Handedness Questionnaire ? Sign an informed consent and pass the safety screening assessment

Exclusion criteria

Exclusion criteria: First episode of low back pain/acute sprain or trauma; Any other type of chronic or recurrent pain; Other neurological diseases or mental illness, epilepsy history; Other clinically relevant pain, pregnancy, or head and neck implants with cochlear implants, pacemakers, and metal stents; paticipating other clinical trials; infectious disease; Alcohol and drug addicts; Low back pain aggravation due to central sensitization.

Design outcomes

Primary

Measure	Time frame
Oswestry disability index;	—

Secondary

Measure	Time frame
visual analogue scale;range of motion of lumbar vertebra;Pain Catastrophizing Scale(PCS);Hamilton Depression Scale;SF-36 scale;loss of working days;the proportion of pain relief ;the proportion of the recurrence of an episode of LBP;P300 amplitude;P300 latency;Oswestry index;	—

Countries

China

Contacts

Public ContactXueli Chen

Beijing Shijitan Hospital, Capital Medical University

chenshirley@126.com+86 133 0116 1888

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026