stroke
Conditions
Interventions
group 1:600 pulses sham iTBS +15 minutes rest +600 pulses sham iTBS +15 minutes rest +600 pulses active iTBS
group 2:600 pulses sham iTBS +15 minutes rest +600 pulses active iTBS +15 minutes rest +600 pulses active iTBS
group 3:600 pulses active iTBS +15 minutes rest +600 pulses active iTBS +15 minutes rest +600 pulses active iTBS
group 4:600 pulses sham iTBS +15 minutes rest +600 pulses sham iTBS +15 minutes rest +600 pulses sham iTBS
Sponsors
China Rehabilitation Research Center, Beijing Bo'ai Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1: First onset or past onset without significant sequelae (pre-stroke modified Rankin Scale score (mRS) =1); 2: Meet the diagnostic criteria for ischemic or hemorrhagic stroke; 3: Course of disease 1-6 months; 4: Age 35-75 years old; 5: Upper limb motor dysfunction caused by unilateral hemispheric stroke (the affected hand or upper limb Brunnstrom stage is between stage ? and stage ?, including stage ? and stage ?); 6: Who understands the trial and signs the informed consent.
Exclusion criteria
Exclusion criteria: 1: The presence of bilateral hemispherical or subtentorial lesions resulting in stroke, brain tumor, brain trauma, fracture and other diseases resulting in neurological impairment, upper limb limitation, mutilation, joint swelling, contracture, severe pain or other hand disorders; 2: MAS scores of shoulder, elbow, wrist and finger muscle tension on the affected side were =3; 3: There are contraindications for MRI scanning such as claustrophobia, and contraindications for TMS therapy; 4: A history of epilepsy; 5: Patients with severe heart, lung, liver, kidney and other systemic diseases that cannot be controlled by conventional drugs are found through laboratory tests and examinations; 6: Patients with severe aphasia (NIHSS speech item =2 points), dyslexia (NIHSS phonology item =2 points), cognitive impairment (MMSE score =20 points), deafness, etc., and unable to cooperate with treatment and evaluation 7: Is participating in other clinical research trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Motor Assessment Scale-Upper Extremity ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wolf Motor Function Test ;Grip Strength;Modified Barthel Index ;Stroke Impact Scale ; | — |
Countries
China
Contacts
Public ContactQianqian Chi
Beijing Bo'ai Hospital
Outcome results
None listed