Postoperative pain, nausea and vomiting
Conditions
Interventions
Esketamine Group(E Group):A single dose of esketamine 0.25 mg /kg is to inject intravenously as laparoscopic withdrawal. After extubation, a single dose of esmketamine 0.1mg/kg is to inject intraveno
Sufentanil Group(S Group):A single dose of sufentanil 0.1µg/kg is to inject intravenously as laparoscopic withdrawal. After extubation, a single dose of sufentanil 0.04µg/kg is to inject intravenously
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Patients and their legal representatives voluntarily participated in the study and signed informed consent. (2) Patients undergoing elective surgery in the Department of gynecology of our hospital, who planned to undergo laparoscopic surgery with endotracheal intubation under general anesthesia, and estimated operation time under 2 hours; (3) Age of 18-60 years old; (4) Preoperative Mallampati grade I-II.
Exclusion criteria
Exclusion criteria: (1) History of taking psychotropic drugs within 3 days before surgery; (2) Unable to complete visual analogue scale (VAS) test or psychological assessment independently; (3) History of severe neuropathic pain such as migraine, diabetic peripheral neuropathy, postherpetic neuralgia, trigeminal neuralgia, post-traumatic neuralgia, phantom limb pain; (4) History of severe craniocerebral trauma or hemorrhage or cerebral infarction; (5) patients with contraindications to ketamine and esketamine; (6) complicated with severe mental illness; (7) abdominal lymph node dissection is required; (8) patients deemed by other investigators to be ineligible for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS grade of Postoperative nausea and vomiting(PONV); | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS grade of wound pain;Dosage and effect of analgesic drugs;The time of first exsufflation; | — |
Countries
China
Contacts
Public ContactLi Xiang
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed