Cognitive impairment in the elderly
Conditions
Interventions
treatment group of subjective cognitive decline(SCD) group:repetitive transcranial magnetic stimulation
control group of subjective cognitive decline(SCD) group :sham repetitive transcranial magnetic stimulation
Sponsors
The Affiliated JiangSu Shengze Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria are based on Jessen’s criteria as follows: (1) not meeting the diagnosis of MCI on the standardized neuropsychological tests, including memory, speed/executive function, and language domains; (2) self-perceived memory loss for at least 6 months; (3) presence of concern that performance in memory is worse than other people of the same age; (4) 55 to 80 years; (5)the subject signs the informed consent.
Exclusion criteria
Exclusion criteria: The exclusion criteria are as follows: (1) clinical diagnosis of vascular dementia (Modified Hachinski Ischemic Score > 4) or dementia (NINDS-AIREN criteria); (2) drug or alcohol dependence within the last 6 months; (3) presence of severe cardiovascular or cerebrovascular disease or psychiatric disease; (4) contraindications to TMS; (5) treatment with antidepressants, anxiolytics, or central nervous system medications within 3 months prior to the assessments; (6) geriatric depression scale scores = 6.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test-Huashan version (AVLT-H) ; | — |
Secondary
| Measure | Time frame |
|---|---|
| mini-mental state examination(MMSE);Wechsler Logical Memory Test ;wechsler digital memory span test ;Boston Naming Test China version(BNT-C) ;Animal Fluency test (AFT);Shape Trail Test-A China version(STT-A-C) ;Shape Trail Test-B China version(STT-B-C) ;Digit Symbol Substitution Test (DSST);motor cortex plasticity ;working memory(n-back) ;inhibition control(Go/No-Go) ;Montreal cognitive assessment (MoCA); | — |
Countries
China
Contacts
Public ContactLu Qian
The Affiliated JiangSu Shengze Hospital of Nanjing Medical University
Outcome results
None listed