type 2 diabetes mellitus
Conditions
Interventions
Impaired fasting glucose(IFG):NA
Impaired fasting glucose tolerance(IGT):NA
type 2 diabetes mellitus,T2DM:NA
control group:NA
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the experimental group: (1) According to the World Health Organization (1999) criteria for diagnosing Type 2 diabetes, the experimental group was divided into three groups: impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus (T2DM). IFG was defined as a fasting plasma glucose level of 6.1 mmol/L or higher but less than 7.0 mmol/L, and an OGTT 2-hour value of 7.8 mmol/L or lower; IGT was defined as a fasting plasma glucose level of 6.1 mmol/L or higher but less than 7.0 mmol/L, and an OGTT 2-hour value of 7.8 mmol/L to 11.1 mmol/L; T2DM was diagnosed when FPG > 7.0 mmol/L. The participants in the experimental group were not receiving medication for T2DM at the time of study. (2) Participants were between the ages of 40 and 60. (3) They were right-handed. (4) Their educational years had been = 6 years. (5) Their Hamilton Depression Scale (HAMD) scores were less than 8. (6) They did not have any eye diseases that affected their writing, nor did they have language barriers. (7) They did not have any history of cognitive impairment due to conditions such as cerebral hemorrhage, large-area stroke, tumor, brain injury, hypothyroidism, vitamin deficiency, anemia, or liver and kidney dysfunction. (8) They had a clear understanding of the study content and signed a informed consent form. (9) They did not have any contraindications for magnetic resonance imaging (MRI). The inclusion criteria for the control group were as follows: Gender, age, educational level, and dominant hand matched with volunteers who met these criteria. (1) They did not have diabetes (FPG < 3.9 mmol/L or 7.0 mmol/L, and OGTT 2h < 7.8 mmol/L). (2) They did not have subjective memory loss. (3) Their MoCA score was greater than or equal to 26. (4) Their MMSE score was greater than or equal to 24. (5) They were between the ages of 40 and 60. (6) They were right-handed. (7) They had an educational year count of at least six years. (8) Their HAMD scores were less than or equal to 8. (9) They did not have any eye diseases that affected their writing, nor did they have language barriers. (10) They did not have any history of cognitive impairment due to conditions such as cerebral hemorrhage, large-area stroke, tumor, brain injury, hypothyroidism, vitamin deficiency, anemia, or liver and kidney dysfunction. (11) They had a clear understanding of the study content and signed an informed consent form. (12) They did not have any contraindications for MRI.
Exclusion criteria
Exclusion criteria: (1) Exclude cognitive impairment caused by clear causes such as brain injury, brain tumor, cerebral hemorrhage, large-area cerebral infarction, depression/anxiety disorder, Alzheimer's disease, Parkinson's dementia, front temporal lobe dementia, Creutzfeldt-Jakob disease, taking consciousness-altering drugs, etc. (2) Exclude alcohol poisoning. (3) Exclude pulmonary heart disease, acute complications of diabetes mellitus, acute infectious diseases, primary nephropathy, and other major diseases such as hyperthyroidism, heart failure, tumors, etc. (4) Exclude white matter lesions: age-related white matter changes (ARWMC) scoring > 1 point (ARWMC standard: 0 points: no lesion, 1 point: local lesions, 2 points: lesions integrated into a patchwork pattern, 3 points: diffuse involvement throughout the region with or without subcortical U-shaped fibers involved> (5) Exclude the contraindications for magnetic resonance imaging. (6) HAMD score > 8 points.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortical Thickness, CT;Sulcus Depth, SD;Gyrification Index, GI;Fractal Dimension, FD;Fractional Anisotropy,FA;Mean Diffusivity,MD;Regional Homogeneity,ReHo;Amplitude of Low-frequency Fluctuation, ALFF;Fractional Amplitude of Low-frequency Fluctuation,fALFF;Functional Connectivity,FC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Axial Diffusivity,AD;Radial Diffusivity,RD; | — |
Countries
China
Contacts
Public ContactZENG ZI SAN
Department of Imaging, The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed