Thyroid related diseases (Graves ophthalmopathy)
Conditions
Interventions
Inactive GO group:None
Active GO group:None
Control group undergoing surgery:None
GO group undergoing surgery:None
Sponsors
First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients who meet the diagnostic criteria for Graves' disease or Graves' ophthalmopathy and have not received immunosuppressive therapy The lender; (2) = 18 years old, ?65 years old; (3) the applicant agrees and signs the informed consent form;
Exclusion criteria
Exclusion criteria: (1) Patients with previous immunosuppressive therapy or optic nerve injury;(For patients undergoing surgical treatment, the use of hormones and immunosuppressants within the last 3 months can be excluded) (2) have been treated with corticosteroids or other immunosuppressants for other reasons within the past 3 months, or have taken probiotics or antibiotics within the past 4 weeks. (3) Patients with acute or chronic viral hepatitis, moderate or severe damage of liver and kidney function, acute infection, severe osteoporosis, high blood pressure and blood glucose, who cannot be controlled; (4) History of chronic diarrhea or constipation, inflammatory bowel disease, malignancy, other autoimmune diseases, history of gastrointestinal surgery, vegetarians; (5) pregnant or breastfeeding; Suspected or real drug abusers, alcohol addicts; (6) has a history of mental illness, or is judged by the investigator to be unfit to participate in the clinical study or unable to cooperate with the completion of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid metabolomics, intestinal flora, magnetic resonance imaging, and fibrocyte autophagy levels between groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, cysteine-rich protein 61 among the groups (CYR61), cytokines (IL-6, IL-17, IL-10), IgG, IgG4, FT3, FT4, TSH, TPOAb, TgAb, TRAb, IOP, fundus photography, CAS score, GO-QOL score, perceived stress score, anxiety and depression score; | — |
Countries
China
Contacts
Public ContactXu Jixiong
First Affiliated Hospital of Nanchang University
Outcome results
None listed