Mild Cognitive Impairment based on Traditional Chinese Medicine constitution
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: ?Patients fulfilling diagnostic criteria for Mild Cognitive Impairment; ?Memory impairment (self-reported and confirmed by an informed person) with an MMSE score between 22 and 27;? Yang deficiency, blood stasis, or phlegm dampness meeting the criteria of the Classification and Determination of Physical Qualities in Traditional Chinese Medicine; ?Age between 55-75 years; ? Relatively normal or mildly impaired cognitive functions other than memory; ?Daily living ability and social occupation remain unaffected; ?Memory impairment did not meet the diagnostic criteria for dementia; ?Exclusion of any systemic diseases potentially causing brain dysfunction; (9) Informed consent signed by the subject or guardian.
Exclusion criteria
Exclusion criteria: ?Those with advanced, severe, or unstable comorbidities, such as liver or kidney disease, or other serious underlying medical conditions. ?Individuals with profound hearing or visual impairment who are unable to cooperate with the assessment. ?Those with active epilepsy. ? Individuals with a history of psychiatric disorders. ?Those with dementia, cerebral infarction, or any neurological or psychiatric disorder that may impact cognitive function.?Individuals who have been previously prescribed medications that may affect cognitive function or vital organs, such as the heart, brain, or kidneys. ?Individuals under 55 or over 75 years old.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental state examination(MMSE);Montreal cognitive assessment(MoCA);auditory verbal learning test-Huashan version (AVLT-H);Animal fluency test ( AFT);Boston Naming Test(BNT);Shape trails test A(STT-A)/shape trails test B(STT-B);Functional Activities Questionnaire(FAQ); | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index(PSQI); | — |
Countries
China
Contacts
First Affiliated Hospital, Guangxi University of Chinese Medicine