lung cancer
Conditions
Interventions
Intervention group:In the intervention group, at the end of the surgery, liposomal bupivacaine injection (266mg/20ml) is administered into the intercostal spaces between the 2nd and 6th ribs, with 4ml
Control Group:In the control group, at the end of the surgery, 0.375% ropivacaine (75mg/100ml) is injected between the 2nd and 6th ribs, with 4ml per intercostal space.
Sponsors
Shaoxing People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients aged =18 years, with ASA physical status I-II, without a history of abnormal bleeding or coagulation disorders, providing informed consent, and undergoing single-port video-assisted thoracoscopic surgery (VATS) for pulmonary lobectomy, segmentectomy, or wedge resection.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to general anesthesia or who are unfit for surgery. 2. Patients allergic to opioids, liposomal bupivacaine, ropivacaine, or any of the investigational drugs or their components. 3. Patients with absolute contraindications to nonsteroidal anti-inflammatory drugs (NASIDs). 4. Patients with contraindications to intercostal nerve block or local infiltrative anesthesia. 5. Patients on long-term use of opioids or psychiatric medications. 6. Patients who have recently participated in other clinical trials involving opioids. 7. Patients with central nervous system disorders, cognitive impairment, or low literacy level, making it difficult to complete pain assessments. 8. Patients with severe kidney or liver damage or comorbidities that may affect postoperative recovery. 9. BMI > 44 kg/m2. 10. Patients who refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale in resting state.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative rescue opioid medication dosage;The dosage of PCA (Patient-Controlled Analgesia) opioids.;Patient satisfaction with overall pain management.; Incidence of adverse events.; | — |
Countries
China
Contacts
Public ContactGuangmao Yu
Shaoxing People's Hospital
Outcome results
None listed