chronic post-surgical pain after knee arthroplasty
Conditions
Interventions
intervention group:During anesthesia induction, intravenous injection of 0.25mg/kg of Esketamine and continuous intravenous infusion of 0.125mg/(kg*h) of Esketamine during surgery
control group:During anesthesia induction, the same volume of physiological saline was injected intravenously as in the intervention group, and the same speed of physiological saline was continuously
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria of knee osteoarthritis; 2. Age =18years old; 3. BMI 18.5-30 kg/m^2 4. ASA grade I-III; 5. Undergoing the first unilateral total knee arthroplasty under elective general anesthesia.
Exclusion criteria
Exclusion criteria: 1. There are contraindications related to the use of Esketamine; 2. Previous history of knee joint injuries and surgeries; 3. Have rheumatic immune system diseases such as rheumatoid arthritis and systemic lupus erythematosus; 4. Have neuromuscular or psychiatric disorders; 5. Complication with severe cardiovascular, cerebrovascular, and pulmonary diseases or severe liver and kidney dysfunction before surgery; 6. Accompanied with cancerous pain; 7. Unable to understand or cooperate in completing relevant scales; 8. Refuse to sign an informed consent form or participate in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative chronic pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numerical Rating Scale;Western Ontario and McMaster Universities Osteoarthritis Index;Hospital Anxiety and Depression Scale;ID Pain Scale; | — |
Countries
China
Contacts
Public ContactShen Wen
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed