Correlation between plasma and cerebrospinal fluid irisin concentrations and postoperative cognitive dysfunction in elderly joint replacement patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300075455

Enrollment

Unknown

Registered

2023-09-05

Start date

2022-03-16

Completion date

Unknown

Last updated

2023-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive dysfunction

Interventions

POCD group:No

Non-POCD group:No

Eligibility

Sex/Gender

All

Age

60 Years to 85 Years

Inclusion criteria

Inclusion criteria: ? is over 60 years old; ? has undergone elective artificial total hip arthroplasty or artificial total knee arthroplasty; ? American Association of Anesthesiologists (ASA) classification: Grade I~?; ? has normal coagulation tests; ? No preoperative cognitive dysfunction;?meets the indications for arthroplasty surgery.

Exclusion criteria

Exclusion criteria: ? has mental dysfunction or taking antipsychotic medication; ? with other pathological diseases (chronic renal failure, hypothyroidism, musculoskeletal, and neurodegenerative diseases), ? severe heart, liver, and renal insufficiency; ? various malignant tumors; ? A history of trauma, stroke or surgery in the past one year;? There are contraindications to lumbar puncture;? Vision and hearing impairment;? Refusing to participate in the study or having incomplete evaluation data

Design outcomes

Primary

Measure	Time frame
irisin;	—

Secondary

Measure	Time frame
TNF-a;IL-6;IL-1ß;Cognitive function;Postoperative pain;	—

Countries

China

Contacts

Public ContactZhang Daiying

The Affiliated Hospital of Southwest Medical University

893388397@qq.com+86 136 0828 8989

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026