oral malignancy
Conditions
Interventions
group P:The plasma concentration of target controlled infusion of propofol was 4.0ug/ml in group P, The plasma concentration of target controlled propofol infusion was set at 2-4ug/ml during the maint
Group C1:The plasma concentrations of cypofol target controlled infusion were set at 0.8ug/ml during induction and 0.4-1.2ug/ml during maintenance of general anesthesia in group C1.
Group C2:The plasma concentrations of cypofol target controlled infusion were set at 1.0ug/ml during induction and 0.4-1.2ug/ml during maintenance of general anesthesia in group C2.
Group C2:The plasma concentrations of cypofol target controlled infusion were set at 1.2ug/ml during induction and 0.4-1.2ug/ml during maintenance of general anesthesia in group C3.
Sponsors
Department of Anesthesiology, the Second Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing radical surgery for oral cancer 2. Age 18-60, gender unlimited 3, BMI18-30kg/m2 4. American Society of Anesthesiologists (ASA) Class ? or ? 5. Clearly understand and voluntarily participate in the study, and sign the informed consent
Exclusion criteria
Exclusion criteria: 1. Participated in other clinical trials within 4 weeks prior to the start of this study 2. Chronic alcoholism or abuse of benzodiazepines and opioids 3. Allergic to benzodiazepines, opioids, propofol or their components; 4, serious heart, liver, lung or renal insufficiency (that is, the index is more than 1 times the normal value) 5. Patients with poorly controlled hypertension 6. Atrial fibrillation 7. Severe cerebrovascular stenosis 8. Suspected difficulty in intubation (Mallampati grade 3-4, mouth opening less than 3.5cm); 9. Dyslipidemia 10. Pregnant or lactating patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative blood pressure and heart rate changes;Loss of consciousness time;The time from induction to WLi < 69;Total dosage of propofol or ciprofol;Blood lipid after operation; | — |
Countries
China
Contacts
Public ContactXiao Feng
Department of Anesthesiology, the Second Xiangya Hospital, Central South University
Outcome results
None listed