A clinical study of collateral pricking and bloodletting at Jing-well points in the treatment of post-stroke cognitive impairment

Based on Nrf2/ARE signaling pathway to explore the mechanism of pricking and bloodletting at Jing-well points in the treatment of cognitive impairment after ischemic stroke.

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300075437

Enrollment

Unknown

Registered

2023-09-05

Start date

2023-10-01

Completion date

Unknown

Last updated

2023-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PSCI

Interventions

control group:conventional treatment? nursing? rehabilitation

intervention group:collateral pricking and bloodletting at Jing-well points

Eligibility

Sex/Gender

All

Age

40 Years to 85 Years

Inclusion criteria

Inclusion criteria: ?Aged 40-85 years old, male or female; ?First stroke, moderate stroke patients with NIHSS score 5-15; ?Cognitive function decline usually occurs within six months after stroke; ?MMSE baseline score 20-26 points, MoCA score = 25 points; ?Patients who are conscious, without aphasia, without severe intellectual impairment, without mental disorders, who can communicate normally and complete the assessment of the scale; ?Consent and voluntarily participate in this clinical research, and sign the informed consent form.

Exclusion criteria

Exclusion criteria: ?Central nervous system diseases other than stroke, such as epilepsy, Parkinson, Alzheimer; ?Severe mental illness or severe depression, long-term use of antidepressants, antipsychotics and other drugs for treatment; ?Combined with Severe heart, liver or kidney disease and or cancer; ? Those with a history of underlying medical conditions that may lead to abnormal cognitive function; ? Pregnant women.

Design outcomes

Primary

Measure	Time frame
Mini–Mental State Examination (MMSE);Montreal Cognitive Assessment (MoCA);	—

Secondary

Measure	Time frame
National Institute of Health stroke scale(NIHSS);Malondialdehyde(MDA);Glutathione (GSH);Superoxide dismutase(SOD);Modified Barthel Index (MBI);the 36-Item Short-Form Health Survey (SF-36);	—

Countries

The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine

Contacts

Public ContactChen Qing

The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine

liqiaoling@stu.hnucm.edu.cn+86 137 8714 2874

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026