Infertility
Conditions
Interventions
LE :letrozole ovulation induction protocol for frozen-thawed embryo transfer
GnRH-a+HRT:hormone replacement therapy with GnRH-a pretreatment protocol for frozen-thawed embryo transfer
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age between 20 and 40 years; 2. Patients diagnosed with endometriosis by laparoscopy or laparotomy, or meeting all of the following criteria: (1) Cyclical and non-cyclical signs and symptoms (dysmenorrhea, dyspareunia, dyschezia, etc.) (2) Palpable nodularities in the pouch of Douglas found on bimanual pelvic examination (3) Endometrioma found by TVS 3. Previous embryo transfer failure cycle is = 2, and previous ovulation cycle is = 2; 4. Performing frozen-thawed single blastocyst transfer, and the blastocyst was morphologically graded as 4BC or better using Gardner grading criteria.
Exclusion criteria
Exclusion criteria: 1. No use of GnRH agonist (3.75mg) within 3 months prior to transfer; 2. Patients with untreated hydrosalpinx; 3. Patients with uterine malformalities (unicornuate uterus, uterus bilocularis, mediastinal uterus) or moderate to severe uterine adhesions, etc.; 4. Patients with a history of canceled FET cycle(s) due to a thin endometrium (<7mm); 5. History of recurrent abortion; 6. Preimplantation genetic screening is required; 7. Patients with untreated diabetes, hypertension, thyroid dysfunction, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Biochemical pregnancy rate;miscarriage rate;Incidence of obstetric and perinatal complications;Incidence of neonatal complications; | — |
Countries
China
Contacts
Public ContactXiang Ma
Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed