Autoimmune encephalitis
Conditions
Interventions
Control group:NA
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Experimental group: ? Age 18 or above, but not exceeding 60 years old. ? Blood or cerebrospinal fluid (CSF) with anti-NMDAR titers greater than 11:1010, with positive results in both blood and CSF. ? Symptoms include abnormal behavior, cognitive impairment, speech disorders, seizures, involuntary movements, coma, central hypoventilation, etc. ? Duration of illness for at least six months, including relapsed patients (relapse defined as the emergence of new symptoms or worsening of symptoms after an initial improvement or stability for at least 2 months). ? Informed consent was obtained from patients and their relatives. Control group: ? Age 18 or above, but not exceeding 60 years old, with age and gender matching. ? Good general health, with a BMI between 18 and 34. ? Basic laboratory tests showing normal results. ? Blood or CSF with negative anti-NMDAR titers.
Exclusion criteria
Exclusion criteria: ? Patients diagnosed with epilepsy, traumatic brain injury, and/or other neurological disorders before the onset of encephalitis, as well as patients diagnosed with myocardial infarction, heart failure, liver diseases (such as cirrhosis, fatty liver, viral hepatitis), other autoimmune diseases excluding AE, and hematological disorders. ? Patients with pre-existing infections, along with bacterial, fungal, parasitic, or viral infections. ? Patients with concomitant tumors, excluding teratomas. ? Patients lacking crucial clinical data. ? Pregnant or breastfeeding patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| differential expressed genes.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale;cognitive function score;Psychiatric scale score;Anxiety self-rating scale score;Depression self-rating scale score;GCS score;CAMS score; | — |
Countries
China
Contacts
Public ContactHong Zhen
West China Hospital, Sichuan University
Outcome results
None listed