Exploring the intervention mechanism of overweight/obesity based on intestinal flora-neuromodulation network for spleen deficiency and dampness trapped evidence

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300075397

Enrollment

Unknown

Registered

2023-09-04

Start date

2023-05-18

Completion date

Unknown

Last updated

2023-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

overweight and obesity

Interventions

Acupuncture group:The patient was positioned supine, and after routine sterilization of the acupuncture points, disposable sterile needles were used to acupuncture Zhongwan, Tianshu (double), Shui Dao

Pseudo-needling group:The patient was positioned supine, and the acupuncture points were routinely sterilized, and the sham acupuncture needles were used to contact but not penetrate the skin, and to

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ?Age 18-65 years, both men and women; ?Meet the criteria for diagnosis of overweight/obesity and identification of spleen deficiency and dampness; ? Relatively stable dietary habits, no special dietary predilections, no serious bad habits such as long-term heavy smoking, alcoholism, drug abuse, etc. in the last 5 years; ? Not having received treatment for weight loss by acupuncture within the last 3 months; ? Voluntarily join and sign the informed consent form.

Exclusion criteria

Exclusion criteria: ?Combined with acute infectious diseases; ? Those with severe liver and kidney insufficiency, heart disease, respiratory disease and malignancy; ? previous hematologic diseases such as diabetes, chronic liver disease, coagulation disorders and acute and chronic gastrointestinal diseases such as chronic inflammation of the gastrointestinal tract, Crohn's disease, gastrointestinal tumors, and history of gastrointestinal surgery and other factors that may lead to disorders of the intestinal flora; ? using or having used antibiotics, laxatives, probiotics or prebiotic preparations within 1 month before enrollment; ? Patients with combined severe hyperuricemia, hyperlipidemia and other metabolic diseases that are poorly controlled by medications; ? Patients with psycho-emotional disorders and those who cannot cooperate with the study; ?Pregnant women, women in pregnancy, perinatal period, lactating women, and perioperative patients; ? Individuals who are usually susceptible to allergies and are allergic to needles; ? Individuals with skin diseases or skin damage at the needling site required for research.

Design outcomes

Primary

Measure	Time frame
Results of neurotransmitter analysis of intestinal flora;	—

Secondary

Measure	Time frame
Results of metabolomic assay of intestinal flora;Waist Circumference;Hip circumference;Body weight;Waist-to-hip ratio;BMI;Body fat percentage;Body fat weight;De-fatted weight;blood pressure;	—

Countries

China

Contacts

Public ContactZeng Huiyan

Guangdong Provincial Hospital of Chinese Medicine

13924011881@126.com+86 139 2401 1881

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026