Chronic obstructive pulmonary disease
Conditions
Interventions
Control group:NIPPV
Sponsors
Hai'an People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: All patients meet the diagnostic criteria for AECOPD (updated in 2017) , GOLD stage I to IV, age>45 years old, PaO250 mmHg.
Exclusion criteria
Exclusion criteria: Patients with sudden cardiac and respiratory arrest requiring emergency tracheal intubation and invasive mechanical ventilation; Weak spontaneous respiration and coma; People with ventilation dysfunction; Extremely severe type I respiratory failure (oxygenation index<60); Hemodynamic instability; Mental state changes and inability to cooperate; Prone to aspiration; The secretion is thick and large in volume; Craniofacial trauma or burns; Fixing nasal foreign bodies; Recent facial or gastroesophageal surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaCO2;PH;PaO2;PaO2/FiO2;HCO3-; | — |
Secondary
| Measure | Time frame |
|---|---|
| Comfort;respiratory rate;Recurrent tracheal intubation rate; | — |
Countries
China
Contacts
Public ContactAingmin Liu
Hai'an People's Hospital
Outcome results
None listed