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The effectiveness of microapical surgery with or without GTR in the treatment of periapical lesions: a randomized controlled clinical trial

The effectiveness of microapical surgery with or without GTR in the treatment of periapical lesions: a randomized controlled clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300075380
Enrollment
Unknown
Registered
2023-09-04
Start date
2023-09-04
Completion date
Unknown
Last updated
2023-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic apical periodontitis

Interventions

control:Microapical surgery
S:Microapical surgery&SIS
B:Microapical surgery&Bio-Gide

Sponsors

Peking University School and Hospital of Stomatology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Patients aged 18-60 years who need micro-apical surgery. (2) CBCT showed periapical lesions with a maximum diameter of 5-10 mm and cortical bone defects. (3) Single anterior teeth or premolars with chronic periapical inflammation requiring apical surgery. (4) PD of the affected tooth (or after periodontal basic treatment) is less than 3mm, and the gingival margin is not obviously red and swollen, and it is not loose.

Exclusion criteria

Exclusion criteria: (1) Preoperative or intraoperative examination found that the affected tooth has a root crack or other reasons need to be removed. (2) Patients with developmental jaw cyst or tumor could not be excluded by preoperative clinical or CBCT examination. (3) To exclude the acute infection, if the acute infection control can be evaluated again screening. (4) Patients with a history of maxillofacial surgery due to tumor/trauma/orthognathic reasons were excluded. (5) Have a serious or uncontrolled systemic disease. (6) Postoperative image examination showed that the quality of root tip preparation and backfilling was not satisfactory.

Design outcomes

Primary

MeasureTime frame
Apical lesion size;

Secondary

MeasureTime frame
The subject has no positive symptoms or signs;

Countries

China

Contacts

Public ContactRentao Tang

Peking University School and Hospital of Stomatology

tantao005@qq.com+86 186 0044 1209

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026