Stroke, depression
Conditions
Interventions
Stroke group:None
Depression group:None
Healthy controls:None
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for stroke patients: (1) Ages ranged from 18-75 years; (2) Patients who met the diagnostic criteria of the 2018 Chinese guidelines for the diagnosis and treatment of acute ischemic stroke; (3) Sign the informed consent form, provide relevant medical history information and provide blood, urine and stool samples. 2. inclusion criteria for depressed patients: (1) Age ranged from 18-75 years; (2) Patients who met the depression related criteria in the Chinese classification and diagnostic criteria for mental disorders; (3) Sign the informed consent form, provide relevant medical history information and provide oral swabs, blood, urine and stool samples. 3. inclusion criteria for healthy control: (1) Non-diseased people from the general community living in the city of their location for the last three years; (2) Sex and age matched with stroke and depression patients, respectively; (3) Signed informed consent, provided relevant medical history information and provided biospecimens.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for stroke and depression patients: (1) Serious systemic diseases including malignancies; (2) Alanine aminotransferase or aspartate aminotransferase >2 times the upper limit of normal value or severe liver disease; (3) Creatinine >1.5 times the upper limit of normal or severe nephropathy; (4) A long-term history of drinking, drug taking and chemical poisoning. A long-term history of drinking refers to a history of more than 5 years, equivalent to alcohol >40g/d for men and 20g/d for women, or a history of heavy drinking within 2 weeks, equivalent to alcohol >80g/d; (5) Those with previous history of intestinal tumor, irritable bowel syndrome or inflammatory bowel disease or diagnosed in Hospital; (6) Unable to retain the required samples. 2.Exclusion criteria for healthy control: (1) History of inflammatory bowel disease, prolonged diarrhea or constipation, malignancy, history of cardiac infarction or any stroke, and history of other major diseases; (2) Use of antibiotics within the last three months; (3) Use of metformin, statins, probiotics/probiotics in the last three months; (4) Recent heavy alcohol consumption or a history of chronic alcohol consumption; (5) History of drug use and chemical poisoning (such as pesticide poisoning).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbiome;metabolome; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale;Modified Rankin Scale;Hamilton Depression Scale;Montgomery-Asberg Depression Rating Scale; | — |
Countries
China
Contacts
Public ContactHongwei Zhou
Zhujiang Hospital of Southern Medical University
Outcome results
None listed