To study the brain function remodeling mechanism of moderate intensity aerobic exercise after stroke based on stroke recovery biomarkers

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300075366

Enrollment

Unknown

Registered

2023-09-01

Start date

2023-09-01

Completion date

Unknown

Last updated

2023-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Intervention group:Regular rehabilitation exercise +40 minutes of moderate intensity aerobic training

Control group:Routine rehabilitation training +40 minutes of rehabilitation knowledge education

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: ? First stroke (ischemic stroke) with a course of 7 days to 6 months; ? The diagnosis of cerebral infarction or cerebral hemorrhage conforms to the consensus of "Diagnostic Essentials of Various Major Cerebrovascular Diseases in China 2019" formulated by the Cerebrovascular Diseases Group of the Neurology Branch of the Chinese Medical Association; ? Cerebral infarction or cerebral hemorrhage confirmed by CT or MRI; ? The age is 18-75 years old; ? Unilateral hemiplegia, Modified Rankin Scale (mRS)=2; ? Mini-mental State Examination (MMSE)=24; ? Vital signs were stable without serious complications; ? Before getting sick, he was judged to be right-handed by Edinburgh handedness questionnaire; Pet-name ruby patients themselves or immediate family members signed informed consent.

Exclusion criteria

Exclusion criteria: ? obvious speech, attention, hearing, vision (unilateral neglect, hemianopia, etc.) and cognitive dysfunction; ? Previous history of brain organic diseases, neuropsychiatry, drug abuse and alcoholism; (3) severe heart, lung, liver, kidney and other important organ failure; ? Patients with acute myocardial infarction, unstable angina pectoris, severe arrhythmia, acute pericarditis, severe aortic stenosis, severe left ventricular dysfunction, uncontrolled hypertension, acute pulmonary embolism or pulmonary infarction, severe lower limb vasculitis or limb dysfunction. ? Severe spasm or pain; ? There are metallic foreign bodies in the body; Patients with claustrophobia; ? Those who can't cooperate with functional evaluation and have poor compliance.

Design outcomes

Primary

Measure	Time frame
VO2max;Exercise load(watt);Anaerobic threshold;	—

Secondary

Measure	Time frame
6-minute walk;Berg Balance Scale,BBS;10m walking speed;Fugl- Meyer Assessment Scale;	—

Countries

China

Contacts

Public ContactJia Jie

Huashan Hospital, Fudan University

Shannonjj@126.com+86 21 5288 7820

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026