Cardiovascular disease
Conditions
Interventions
Gold Standard:Coronary angiography and flow reserve fraction
Index test:Coronary CTA
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: a. Age =18 years and = 80 years; b. Able to understand the purpose of the study, voluntarily participate and sign the informed consent; c. The investigators evaluated the suspected presence of coronary stenosis and planned to perform coronary angiography. Inclusion criteria for CCTA images: a. CCTA should be performed on Canon Medical 320-row CT (Aquilion ONE GENESIS Edition); b. CCTA images are clear and readable; c. Calcification score >100 or the presence of stents was assessed by CCTA imaging.
Exclusion criteria
Exclusion criteria: General exclusion criteria: a. Pregnant or lactating women or women planning to become pregnant; b. History of myocardial infarction within 30 days prior to CCTA; c. Previous coronary artery CABG, pacemaker implantation, ICD, artificial valve; d. Known allergy or contraindication to contrast agents; e. hypertrophic obstructive cardiomyopathy or severe heart failure (NYHA=III); f. Body mass index > 35kg/m2; g. Serum creatinine > 178µmol/L; h. Other conditions in which the subjects were assessed by the investigator as unsuitable for study participation. Exclusion criteria for CCTA images: a. Poor CT imaging quality, unable to extract coronary tree; b. Target lesions were occlusive lesions; c. Lesions involving aneurysms or myocardial Bridges. Exclusion criteria of coronary angiography: a. The target vessel is severely tortuous, and the pressure guide wire is expected to have difficulty passing through.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| stenosis degree;CT-FFR;Accuracy ;Sensitivity ;Specificity ; | — |
Countries
China
Contacts
Public ContactYining Wang
Peking Union Medical College Hospital
Outcome results
None listed