Clinical Efficacy and Safety Evaluation of Huoyang Zhitong Ointment in the Treatment of Knee Osteoarthritis and Synovitis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300075358

Enrollment

Unknown

Registered

2023-09-01

Start date

2023-09-01

Completion date

Unknown

Last updated

2023-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis with Synovitis

Interventions

Experimental group:External Application Yang-Replenishing Pain Relief Ointment

blank group:Placebo of External Application Yang-Replenishing Pain Relief Ointment

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1)Meet the diagnostic criteria for knee osteoarthritis and knee synovitis; 2) Knee osteoarthritis Kellgren & Lawrence grade (= grade II); 3) No treatment for knee osteoarthritis in the past 2 months; 4) Age between 30 and 70, any gender; 5) Patients voluntarily participate in this study and have read and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1) Patients with secondary knee osteoarthritis caused by other diseases, such as joint trauma, congenital or genetic diseases, etc.; 2) Allergy to the study drug or with skin breaks, rash, infection, etc. around the knee joint; 3) Pregnant or lactating women, those who plan to give birth, donate sperm or eggs within one month; 4) Patients who have participated in any other clinical trials in the past 3 months; 5) Those who do not want to accept research measures or cannot collaborate due to mental illness or other conditions; 6) Patients with severe primary diseases such as heart, brain, liver, kidney, and hematopoietic system; 7) Patients who have received medication for knee osteoarthritis or synovitis within one week, which may affect the evaluation of effectiveness and safety indicators; 8) Other factors that the researchers consider unsuitable for participation in the trial.

Design outcomes

Primary

Measure	Time frame
The depth of the knee joint effusion;Knees temperature difference;	—

Secondary

Measure	Time frame
VAS pain score;Western Ontario and McMaster University Osteoarthritis Index;Assessment of daily living ability;Safety assessment;	—

Countries

China

Contacts

Public ContactHouyin Shi

Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University

623340767@qq.com+86 136 7967 9283

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026