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Characteristic analysis and mechanism exploration of yawn-induced paralyzed limb movement enhancement in stroke population

Characteristic analysis and mechanism exploration of yawn-induced paralyzed limb movement enhancement in stroke population

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300075353
Enrollment
Unknown
Registered
2023-09-01
Start date
2023-09-01
Completion date
Unknown
Last updated
2023-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

stroke group:After receiving the yawn video induction, try to induce yawn through yawn-like breathing while completing forearm lifting and grasping movements.
normal group:After receiving the yawn video induction, try to induce yawn through yawn-like breathing while completing forearm lifting and grasping movements.

Sponsors

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Stroke group: ? Aged 18-70 years old, male or female; ? Within 3 months after the first attack of stroke, the symptoms and imaging are clearly diagnosed; ? Yawning in the paralyzed limb induces obvious PBO phenomenon in the arm; ? There is limb motor dysfunction, the Fugel-Meyer motor function score is =85 points, and the upper limb score is =38 points; ? Vital signs remain stable for more than 48 hours; ? The subject has certain cognitive learning ability and can correctly follow simple instructions; ? Agree and sign the informed consent form; Healthy control group: Healthy volunteers (required to start drinking beverages containing caffeine one day before the test)

Exclusion criteria

Exclusion criteria: Stroke group: ? Past medical history of stroke; ? Excessive spasticity of the upper/lower limbs, modified Ashworth classification grade 3 or above; ? Other conditions that significantly affect the patient's upper and lower limb functions, such as: joint muscle contracture, severe frozen shoulder, fracture, arthritis, local skin ulcers on the limbs, pressure ulcers, recent surgical incisions, etc.; ? Those with severe cognitive dysfunction and unable to communicate effectively with medical staff; ? Those who have orthopedic surgery, rheumatism or other diseases that limit upper limb movement; ? Other conditions that the researcher believes are inappropriate for participation in the trial, such as severe hypertension, coronary heart disease, etc. Healthy control group: None

Design outcomes

Primary

MeasureTime frame
Task-state functional NMR;electromyographic amplitude of Extensor carpi radialis muscle ;

Countries

China

Contacts

Public ContactXiaohua Han

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

hanxiao1470@sina.com+86 136 5983 9327

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026