asthma
Conditions
Interventions
Trail group:None
Sponsors
SHANGHAI GENERAL HOSPOTAL
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age from 18 to 70 years 2.With recurrent variable symptoms of dyspnea, cough, wheeze, or chest tightness of at least 8 weeks’ duration. 3.Have undergone the spirometry and methacholine (MCH) bronchoprovocation test, IOS, FENO, and high-resolution computerized tomography (HRCT, GE Medical System; slice thickness 0.625 mm) from September 2013 to December 2019. 4.predicted FEV1 of 80% or greater and FEV1/FVC=0.7, normal HRCT results.
Exclusion criteria
Exclusion criteria: 1.Had respiratory tract infections in the past 8 weeks; 2.Peripheral blood test indicating abnormal hemoglobin, platelets or neutrophils; 3.Use of montelukast, long-acting ß2-agonists, theophylline, anticholinergic agents, or inhaled or oral corticosteroids in the previous 4 weeks; 4.Having concomitant severe systemic diseases. 5.Had more than a 10 pack-year smoking history, who currently smoked, or who had quit smoking less than 2 years earlier.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| spirometry(FEV3-FEV1)/FVC; | — |
Secondary
| Measure | Time frame |
|---|---|
| MCH BPT: methacholine bronchoprovocation test;IOS: impulse oscillometry;FENO: fractional exhaled nitric oxide; | — |
Countries
China
Contacts
Public ContactMin Zhang
Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed