Effects of ciprofol on intraoperative blood pressure, cerebral oxygen and postoperative delirium in elderly patients undergoing thoracoscopic surgery for lung cancer

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300075345

Enrollment

Unknown

Registered

2023-09-01

Start date

2023-05-01

Completion date

Unknown

Last updated

2023-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Group C (ciprofol group):Anesthesia induction: intravenous administration of sufentanil 0.4-0.5 µg/kg, ciprofol 0.3-0.4 mg/kg, administration time 30s. When the eyelash reflex disappears and the BIS v

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? No contraindications for anesthesia ? Perform thoracoscopic single lung ventilation surgery for lung cancer, with OLV time = 60 minutes. ? Age 65-80 years old; ? BMI index 18-30; ? I have not undergone any major or medium-sized surgery in the past three months ? Informed consent recipient

Exclusion criteria

Exclusion criteria: (1) Those who are allergic to the anesthetic drugs used in this study; (2) History of abuse and addiction of alcohol, sedative and analgesic drugs, psychotropic substances or other substances; (3) Patients who cannot cooperate with the completion of the Mini-Mental State Test (MMSE) or whose score is lower than the corresponding minimum score (illiteracy =17, primary school level =20, secondary school level =22, university level =23); (4) Patients with a history of stroke, transient ischemic attack (TIA), moderate to severe craniocerebral vascular stenosis, and a history of craniocerebral trauma or preoperative SctO2 176umol/L, blood urea nitrogen BUN>7.1mmol/L, albumin <30g/L, etc.); (6) Forehead skin damage; (7) The patient refuses to participate

Design outcomes

Primary

Measure	Time frame
Blood pressure;	—

Secondary

Measure	Time frame
Cerebral oxygen ;Postoperative delirium incidence rate;Quality of awakening treatment;MAP, HR, SpO2, SctO2 at each observation time point;MAP mean value;Mean, minimum, and magnitude of decrease in SctO2;The incidence of intraoperative SctO2 desaturation; The incidence of POD; The incidence of other perioperative adverse reactions;;Dosage of anesthetics and vasoactive drugs;The relationship between the incidence of POD and blood pressure and cerebral oxygen;	—

Measure

Time frame

Cerebral oxygen ;Postoperative delirium incidence rate;Quality of awakening treatment;MAP, HR, SpO2, SctO2 at each observation time point;MAP mean value;Mean, minimum, and magnitude of decrease in SctO2;The incidence of intraoperative SctO2 desaturation; The incidence of POD; The incidence of other perioperative adverse reactions;;Dosage of anesthetics and vasoactive drugs;The relationship between the incidence of POD and blood pressure and cerebral oxygen;

—

Countries

China

Contacts

Public ContactHuang Zeqing

Liaoning Cancer Hospital

huangzeqing1973@163.com+86 189 0091 7545

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026