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non-invasive ventilation facemask versus high-flow nasal cannula oxygen for preoxygenation before intubation of general anesthesia in obese pregnant women: a randomized, open-label trial

non-invasive ventilation facemask versus high-flow nasal cannula oxygen for preoxygenation before intubation of general anesthesia in obese pregnant women: a randomized, open-label trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300075328
Enrollment
Unknown
Registered
2023-09-01
Start date
2023-09-01
Completion date
Unknown
Last updated
2023-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preoxygenation Before Intubation in obese pregnant women

Interventions

non-invasive ventilation facemask:Traditional facemask pre-oxygenation was done breathing 100% oxygen with a tightly held facemask and a fresh gas flow of 10 L/min delivered via a circle system
High-flow nasal cannula oxygen:A flow of 50 L/min,37 Celsius heated and humidified 100% oxygen via a nasal cannula was delivered. The nasal cannula was left in place through the entire intubation proc

Sponsors

Shanghai First Maternity and Infant Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1)ASA II-III; 2)aged 18-45 years; 3)BMI >30 kg/m2; 4)gestational age greater than 37 weeks, healthy singleton parturients ; 5)undergo elective cesarean section with general anesthesia.

Exclusion criteria

Exclusion criteria: 1)Maternity with combined systemic or chronic diseases; 2)Presence of respiratory comorbidities may affect respiratory and gas exchange; 3)Only breathe through the mouth.

Design outcomes

Primary

MeasureTime frame
PaO2 before oxygen administration;PaO2 immediately after 3 min preoxygenation;—

Secondary

MeasureTime frame
PaO2 immediately after the intubation;Arterial blood gas analysis of the parturients;FetO2 of the parturients immediately after the intubation;lowest SpO2 during intubation;blood gas analysis of Umbilical vein;blood gas analysis of Umbilical Arterial;—

Countries

China

Contacts

Public Contactzhou shuangqiong

Shanghai First Maternity and Infant Hospital

zsq628628@163.com+86 139 1617 4158

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026