schizophrenia
Conditions
Interventions
Group A:right medial superior frontal gyrus+drug treatment
Group B:left dorsolateral prefrontal cortex stimulation+drug treatment group
Group C:right medial superior frontal gyrus pseudo stimulation+drug treatment
Sponsors
The Second Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Outpatients or inpatients; 2. This episode meets the clinical diagnostic criteria for DSM-5 schizophrenia; 3. Age: 18-45 years old; Gender unlimited; Han Chinese; 4. PANSS score = 60 points; 5. Obtain written informed consent from the patient. If the patient is incapacitated or a minor during the onset of the disease, they must obtain written informed consent from their legal guardian; 6. Those who have no abnormal findings during physical examination; Vital signs, general physical examination, blood routine, urine routine, blood biochemistry, and electrocardiogram are all normal; 7. Those without contraindications to MRI scanning.
Exclusion criteria
Exclusion criteria: 1. Those whose physical examination does not meet the above subject standards; 2. Those who meet the DSM-5 diagnostic criteria for depression, schizophrenic affective disorder, mental developmental delay, generalized developmental disorder, delirium, dementia, memory impairment, or other cognitive impairments; 3. Those suffering from severe unstable physical diseases; 4. Diagnosed diabetes, thyroid disease, hypertension, heart disease, etc; 5. Narrow angle glaucoma; 6. Therapists with suicidal tendencies; Individuals with a history of epilepsy, excluding those with high fever seizures; 7. Patients who meet the DSM-5 diagnostic criteria for alcohol and drug dependence (excluding nicotine dependence); 8. Have used tDCS or rTMS three months before joining the group; 9. Those who have used ECT treatment in the first six months of enrollment; 10. Suffering from or having previously suffered from drug-induced malignant syndrome; 11. Those who suffer from or have previously suffered from drug-induced malignant syndrome or severe delayed motor disorders; 12. Pregnant or lactating women, or those planning to conceive; 13. Patients with head injury accompanied by consciousness disorders for more than 5 minutes; 14. Contraindications to magnetic resonance imaging (when signing the informed consent form, a complete magnetic resonance safety review form is required); 15. Those who have installed ear hearing aids or any metal implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The positive and negative syndrome scale, PANSS;Scale for Assessment of Negative Symptoms, SANS; | — |
Countries
China
Contacts
Public ContactYang Yongfeng
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed