The lesion does not involve the whole layer of infectious corneal disease
Conditions
Interventions
Experimental Group:Acellular keratoplasty
Sponsors
Henan Provincial Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The best corrected vision before surgery is <0.05; the corneal lesion is located in the pupil area. (2) The lesion involves the corneal matrix, but has not yet affected the entire corneal layer of infectious corneal disease (fungal, bacterial, viral)Sexual and spinous amoeba keratitis patients; (3) 18 to 80 years old, male or female; (4) Informed consent: The doctor shall inform the relevant content of the clinical trial in detail, and the patient shall agree and sign the informed consent form. (5) Patients whose infection has not been controlled after more than 2 weeks of non-surgical treatment.
Exclusion criteria
Exclusion criteria: (1) Serious heart, liver, kidney and other important organ diseases; (2) Severe blood and endocrine system diseases and medical history; (3) Mentally abnormal people; (4) Combined with other diseases that affect vision; (5) Corneal perforation; (6) Corneal burns or chemical injuries; (7) Patients with severe vascularization of the cornea caused by corneal diseases; (8) Severe dry eye; (9) Incomplete closure of the eyelids; (10) Severe allergic constitution and/or allergic to test materials; (11) Patients with infectious endophthalmitis; (12) Patients with monocular or loss of vision in the opposite eye; (13) Patients with collagen connective tissue disease throughout the body; (14) Those who cannot accept pig-derived materials because of religious beliefs; (15) Pregnant women, lactation, or women who plan to prepare for pregnancy within 1 year; (16) Researchers believe that it is not suitable for participants in this clinical trial; (17) Those who have participated in any other clinical trials within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| De-blindness rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative observation time: 3 days after operation, 7 days after operation, 30 days, 60 days, 90 days, 180 days, 360 days Except for 6 months after operation, that is, 180 days after operation (visit 6), the visual acuity of other visiting points. All follow-up points: ocular irritation, conjunctival congestion, corneal epithelial healing, control of primary infection, cornea. Transparency, corneal edema, corneal neovascularization, corneal dissolution or exfoliation, slit lamp examination a; | — |
Countries
China
Contacts
Public ContactLiyaWang
Henan Provincial Eye Hospital
Outcome results
None listed