Osteoarthritis
Conditions
Interventions
Aripiprazole tablet Group:Take Eriscimab tablets orally at a dose of 0.1 twice daily
Sponsors
The First People's Hospital of Shuangliu District, Chengdu City
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age > 40 years old; diagnosed with osteoarthritis, experiencing joint pain symptoms, and a VAS score of 70mm= at baseline period =30mm; no oral or topical non-steroidal analgesics, opioid analgesics or glucosamine drugs were used within the week prior to enrollment; no history of bleeding, asthma, severe heart/liver/kidney dysfunction or allergy to non-steroidal drugs; patients are willing and able to provide signed informed consent before any study-related procedures.
Exclusion criteria
Exclusion criteria: Pregnant and lactating women or women of childbearing age who are planning to conceive; patients known to be allergic to non-steroidal anti-inflammatory drugs; patients who have participated in other drug clinical trials within the past month; patients who have received intra-articular injection therapy for joint cavity within the past month; patients who have received steroid treatment within the past month; patients who have undergone knee or hip surgery causing pain or affecting joint function in the 3 months prior to enrollment; other concurrent diseases or complications that may affect efficacy observation (such as local skin damage, infection, rash); Patients with aspirin-induced asthma or a history of bronchial asthma, coronary artery bypass grafting (CABG) perioperative period patients, those with a history of gastrointestinal bleeding or perforation after using non-steroidal anti-inflammatory drugs, active digestive tract ulcers/bleeding, or those with a history of recurrent ulcers/bleeding. Severe heart failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee joint function (WOMAC) and Lysholm score, shoulder joint function score were evaluated using the Constant-Murley Shoulder Assessment Form.;SF-36 Health Survey; | — |
Countries
China
Contacts
Public ContactZhong Gang
Department of Orthopedics, First People's Hospital of Shuangliu District, Chengdu City; West China Hospital of Sichuan University
Outcome results
None listed