end-stage renal disease
Conditions
Interventions
Remimazolam group:sedated with remimazolam and maintained until the end of surgery
Dexmedetomidine group:sedated with dexmedetomidine and maintained until the end of surgery
Sponsors
Department of Anesthesiology, West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. age older than 18 years 2. ASA physical status score of III or IV 3. Patients with end-stage renal disease undergoing peritoneal dialysis tube placement or removal 4. signed the informed consent form
Exclusion criteria
Exclusion criteria: 1. Severe arrhythmia, such as HR=50 bpm at rest, third-degree atrioventricular block, frequent ventricular premature beat, QTc: male=450 ms, female=470 ms 2. Acute heart failure, unstable angina pectoris, myocardial infarction in the last 6 months, current heart failure (NYHA Classes III and IV) or severe valvular heart disease 3. uncontrolled hypertension with antihypertensive drugs [systolic blood pressure (SBP) = 160 mmHg when sitting and/or diastolic blood pressure (DBP) = 100 mmHg when sitting], SBP = 90 mmHg when sitting 4. Existing mental illness, taking psychotropic drugs for a long time, or cognitive dysfunction 5. Known contraindication to benzodiazepines or dexmedetomidine 6. Pregnant or lactating women 7. Other circumstances deemed by the researchers as inappropriate to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| time of onset of sedation;number and rate of body movement during operation;duration of Anesthesia maintained a BIS value of 80;recovery time;rate of bradycardia;rate of hypotention;rate of hyoxemia;PONV;pain score; | — |
Countries
China
Contacts
Public ContactLiang Peng
Department of Anesthesiology, West China Hospital of Sichuan University
Outcome results
None listed