postoperation pain
Conditions
Interventions
experimental group:Local perianal infiltration with bupivacaine liposomes
control group:Local perianal infiltration with ropivacaine
Sponsors
the Third Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Elective hemorrhoidectomy; (2) Age of 18-75 years old, male or female; (3) American Society of Anesthesiologists (ASA) grade ?-? or medically stable grade ?
Exclusion criteria
Exclusion criteria: Exclusion criteria: (1) body mass index (BMI) 30kg/m2. Body mass index = weight/height squared in kg/m2. (2) contraindications to intraspinal anesthesia. (3) difficult airway, acute respiratory infection and asthma attack. (4) uncontrolled severe hypertension or hypotension (systolic blood pressure =160 mmHg, diastolic blood pressure =100 mmHg, systolic blood pressure =90 mmHg, diastolic blood pressure =60 mmHg, any one of these can be met), severe arrhythmia, unstable angina pectoris. Preoperative bradycardia (heart rate 2×ULN). (6) A history of drug use and/or heavy alcohol use, defined as drinking an average of more than 2 units of alcohol per day (1 unit =360 mL of beer or 45 mL of 40% liquor or 150 mL of wine) in the 2 years before the screening period. (7) patients with a history of stroke within 6 months or with sequelae of stroke. (8) history of mental illness or long-term use of psychotropic drugs or chronic analgesics. (8) Allergic to ropivacaine hydrochloride injection, bupivacaine liposome and its drug components. (9) Participated in other drug clinical trials as a subject within the past 3 months. (10) Patients who were deemed by the investigator to be ineligible to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting NRS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise NRS pain score;The time of first ambulation after Surgery;the pain score of ambulation on the 1st, 2nd and 3rd day after Surgery;pain score during defecation within 72 hours;the proportion of NRS pain score ?4 during ambulation and defecation;total use of rescue analgesics;Proportion of subjects receiving rescue analgesics;Incision evaluation on postoperative day 1, 3, and 7; | — |
Countries
China
Contacts
Public ContactHuang Yanjuan
the Third Affiliated Hospital of Guangxi Medical University
Outcome results
None listed