Moyamoya disease
Conditions
Interventions
Group P:The target plasma concentration during propofol induction was 4-6 µg/ml
Target-controlled plasma concentration was 4 ~ 6µg/ml and TCI remifentanil was 4 ~ 8ng/ml.
Group E:The target plasma concentration at induction was 0.6-0.8ug /ml
Target-controlled plasma concentration was maintained at 0.2-0.4 µg/ml, and TCI remifentanil was 4-8 ng/ml
Group S:During induction, the flow rate of 8% sevoflurane O2 was 8L/min and the oxygen content was 80%. The maintenance time was 2.5-3% sevoflurane and TCI remifentanil 4-8 ng/ml
Sponsors
Peking University International Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with confirmed ischemic MMD and STA-MCA revascularization/intraspinal spinal cord occupying. Age: 18 ~ 65 years old. Education level above primary school (can cooperate with neurological function detection). ASA Class I to II. The estimated operation time less than 4h. The patients and their families were informed about the study before operation and signed the informed consent.
Exclusion criteria
Exclusion criteria: Patients with severe bilateral lesions. Combined with severe cardiac, liver and renal damage. Patients who have previously received revascularization therapy. Patients with hearing impairment. History of neurosurgery. Preoperative systolic blood pressure =180mmHg. Diseases that may cause changes in cognitive function (craniocerebral trauma, intracranial tumors, dementia, Parkinson's disease, etc.). The adrenal cortex function is low. Contraindications of magnetic scanning. Patients who were transferred to ICU after operation without extubation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ASL measured changes in CVR in patients with MMD induced by propofol/etomidate/sevoflurane during perianesthesia (before anesthesia and 10 minutes after BIS remained stable between 40 and 60).; | — |
Secondary
| Measure | Time frame |
|---|---|
| The changes of brain functional network and brain function in patients with MMD were monitored perioperative with EEG and rs-fMRI (before anesthesia and 10 minutes after BIS remained stable between 40 and 60);Correlation between cognitive function scale and NSE before surgery and the day before discharge; | — |
Countries
China
Contacts
Public ContactYao Lan
Peiking University International
Outcome results
None listed