Neuroendocrine carcinoma of the cervix
Conditions
Interventions
Trastuzumab Group (Treatment Group):Trastuzumab was administered in a 3-week regimen with an initial loading dose of 8mg/kg, followed by 6mg/kg administered every 3 weeks, and repeated 6mg/kg administ
The first infusion time is about 90 minutes. If the patient has good tolerance during the first infusion, the subsequent infusion can be changed to 30 minutes.
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Female, age = 18 years old; 2) NECC treated at Peking Union Medical College Hospital has undergone standard treatment (chemotherapy regimen based on small cell lung cancer, etoposide+cisplatin/carboplatin), but the condition still relapses/progresses; 3) There is HER2 over-expression; 4) The patient's Eastern Oncology Collaborative Group (ECOG) physical fitness score is 0-2; 5) Karnofsky score = 70 points;
Exclusion criteria
Exclusion criteria: 1) The patient is generally unable to tolerate chemotherapy and oral medication treatment; 2) Patients who are known to be allergic to trastuzumab drugs; 3) Immunohistochemical testing of tumor samples suggests no overexpression of HER2 or mutations in RAS and BRAF genes; 4) Patients with severe acute infections; 5) Patients with other serious or uncontrollable diseases; 6) Patients with case records who have participated in any clinical study of other investigational drugs or medical devices within 30 days prior to medication, except for observational studies; 7) Researchers believe that there are any other factors that are not suitable for inclusion or that affect participation or completion of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival;Overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction;Changes in the size of solid tumor lesions; | — |
Countries
China
Contacts
Public ContactXiao-chen Song
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed