End-stage liver disease in adults
Conditions
Interventions
Group 2:S-ketamine
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients who will undergo liver transplantation at Tianjin First Central Hospital 2) Age 18 to 65 years old 3) ASA ?~? 4) Cardiac function classification ?~?
Exclusion criteria
Exclusion criteria: 1) Previous history of liver transplantation 2) History of myocardial infarction or heart failure within the last 6 months 3) mean pulmonary artery pressure = 25 mmHg; Intracranial hypertension (intracranial pressure = 20 mmHg) 4) Untreated hypertension (level II and above) 5) Preoperative combination of hepatic encephalopathy, respiratory failure and renal failure 6) History of anesthetic drug allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cTn-I;CK-MB;NT-proBNP;miRNA208a; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure;Postoperative extubation time;ICU Length of Stay;CVP;PCWP;SVV;CO;SVO2;Serum Cytokines (TNF)- a ? IL6, HMGB1, and IL-10);Adverse cardiac events (myocardial ischemia (ST segment depression or elevation greater than 1mm for more than 5 minutes), bradycardia, ventricular premature beats, atrial fibrillation, supraventricular tachycardia, myocardial infarction); | — |
Countries
China
Contacts
Public ContactJianGang Xu
Tianjin First Central Hospital
Outcome results
None listed