Perioperative cognitive dysfuntion
Conditions
Interventions
Group H 1(Sodium Bicarbonate Ringer's solution AHH group):Sodium Bicarbonate Ringer's solution 10 ml/kg for AHH
Group H 2(Ringer's solution AHH group):Ringer's solution 10 ml/kg for AHH
Group C (Control group):No hemodilution
Sponsors
YantaishanHospital, Yantai City
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 90 patients with lumbar spondylolisthesis and fracture ,ASAI-III, 65-80 years old, 60-80 kg , no obvious abnormality of heart, lung, liver and kidney function, no history of alcoholism and drug addiction,Hemoglobin (HB)=110g/L, hematocrit (HCT)=35% , platelet (PLT)= l00xl09/l, normal coagulation function; Sign the informed consent form voluntarily
Exclusion criteria
Exclusion criteria: Patients with severe heart, brain, vascular disease, hypertension, diabetes mellitus, hypoalbuminemia, water-electrolyte imbalance, psychosis, neurological disorder and cognitive impairment, those who could not cooperate with the questionnaire, long-term or recent use of sedatives, allergy to any drugs in this study, and those who did not agree to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure (MAP) , Heart rate (HR) , Central venous pressure (CVP) , Cardiac output (CO) , Stroke volume variation (SVV) ,;Electrolytes such as Na+ and K+, Arterial oxygen pressure (PaO2), Arterial blood oxygen saturation(SaO2), Arterial oxygen content (CaO2), Jugular venous oxygen content (CjvO2), Arterio-jugular venous oxygen content difference (Da-jvO2) and Cerebral oxygen extraction rate,CERO2);Perioperative cognitive function;Incidence of perioperative delirium;S100ß and Neuron-specific enolase(NSE); | — |
Countries
The People's Republic of China
Contacts
Public ContactWang Chenghai
YantaishanHospital, Yantai City
Outcome results
None listed