Steatotic liver disease
Conditions
Interventions
Gold Standard:Pathology or MRI-PDFF
Index test: Ultrasound derived fat fraction
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: a. Adults aged =18 years old; b.Diffuse or heterogeneous fatty liver by conventional ultrasound; c. Meet the diagnostic criteria for SLD (Steatotic Liver Disease) established by international experts: diagnosed with hepatic steatosis through imaging or liver histology. This includes metabolic dysfunction-associated steatotic liver disease (MASLD), MASLD with a history of heavy alcohol intake (MetALD), other specific causes such as alcohol-induced, drug-induced, monogenic inherited SLD, and idiopathic SLD; d. Those planning to undergo liver histopathology examination or MRI-PDFF assessment of the degree of hepatic steatosis; e. Agree to participate in this study and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: a. Age <18 years; b. Pregnant or breastfeeding women; c. No eligible liver histopathology examination or MRI-PDFF results prior to the examination, and unwillingness to cooperate with the relevant examinations after completing the UDFF examination. d. Liver transplant patients; e. Refusal to sign the written informed consent form.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| liver stiffness; | — |
Primary
| Measure | Time frame |
|---|---|
| Ultrasound derived fat fraction;ROC curve;accuracy;specificity; | — |
Countries
China
Contacts
Public ContactWenwu Ling
West China Hospital of Sichuan University
Outcome results
None listed