Knee osteoarthritis
Conditions
Interventions
Experimental group:2% ketoconazole cream, 1FTU/joint/day applied to the affected joint
Sponsors
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age > 40 years old and < 60 years old, and clinically diagnosed as knee osteoarthritis according to ACR criteria. 2. The joint pain lasts for more than 6 months and most of the time in the last month, the patients with WOMAC pain score = 8 after physical therapy and first-line NSAIDs treatment; 3. X-rays showed Kellgren and Lawrence grade 2 or 3 osteoarthritis. 4. Those who are not willing to receive intraarticular steroid therapy or opioid medication for pain control. 5. Those who are willing to cooperate with the investigation and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have had surgery on the joint or plan to have surgery on knee. 2. Suffering from other diseases such as: systemic or inflammatory joint disease (rheumatoid arthritis), history of crystalline or neuropathic joint disease, other muscle, joint or nervous system diseases that affect the function of the lower limbs. 3. History of allergy to ketoconazole. 4. There is immunosuppression or acute infection. 5. Have or have had malignant tumors. 6. Have any other medical conditions that cannot participate in the study, including contraindications to MRI, such as cardiac pacemakers. 7. Pregnancy. 8. Body mass index (BMI) > 40 kg/m2. 9. Inability to understand written and spoken Chinese. 10. Have any history of mental and psychological diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC total score;WOMAC joint stiffness score;WOMAC Physical Function Score;MOAKS hoffa's synovitis score;MOAKS synovitis-effusion score;MOAKS Bone marrow lesions score; | — |
Countries
China
Contacts
Public ContactJunjie Gao, Changqing Zhang
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed