SEPSIS
Conditions
Interventions
Observation group:None
Sponsors
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Emergency or ICU patients; (2) Age = 18 years old and = 80 years old; (3) First visit patients with onset time not exceeding 7 days; (4) Meet the two criteria of SIRS (? body temperature:>38 ? or90 beats/min. ? respiration:>20 beats/min or hyperventilation causing paCO212 × 10/l or10%); (5) Suspect infection (such as fever, chills, general fatigue, etc.).
Exclusion criteria
Exclusion criteria: (1) Refractory shock (i.e. expected patient death within the first 24 hours); (2) Inability to achieve source control (i.e. irreversible disease status, such as unresectable dead intestines); (3) Life expectancy before sepsis<3 months; (4) Severe chronic heart failure (NYHA level 4); (5) Children Pugh C-grade or liver transplant recipients; (6) HIV patients with CD4+count<200 cells/mm3 (7) Organ transplant recipients or long-term use of steroids or immunosuppressants; (8) Pregnant (9) Patients who have lost their ability to take care of themselves (10) Those who receive chemotherapy or radiotherapy within 30 days; (11) Severe traumatic brain injury (i.e. CT scan with evidence of nerve damage, GCS<8); (12) Permanent sensory and/or motor deficits caused by spinal cord injury; (13) Unable to obtain informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lymphocyte subpopulation;Third generation macro gene sequencing;Second generation macro gene sequencing; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital sign;Glasscow Score;APACHEII score;SOFA SCORE;blood gas analysis;blood routine;blood biochemistry test;urine routine;chemokine test;coagulation test;lactase;microbial cultivation;Procalcitonin; | — |
Countries
CHINA
Contacts
Public ContactWei Zhu
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology
Outcome results
None listed