Alzheimer disease
Conditions
Interventions
Multi-domain intervention group:Nutritional intervention + group exercise + group cognition + cardiovascular risk factor management
Control group:Regular health education
Sponsors
Wuhan University of Science and Technology
Eligibility
Sex/Gender
All
Age
60 Years to 77 Years
Inclusion criteria
Inclusion criteria: (1) are 60 to 77 years of age from China HEAD cohort, and are living in a sampling neighborhood; (2) have CAIDE in the upper quartile of the cohort (values above 75%); (3) meet at least one of the following criteria: A) Mini-Mental State Examination (MMSE) (z score) between 0 and -1.0, B) learning task (z score) <0, and C) delayed recall (z score) <0; (4) meet any item of A-D: A) carriers of ApoEe4 allele, B) first-degree family history of significant memory impairment, C) have one of the Aß (Aß42/40) and Tau (p-Tau 181 and p-Tau 217) pathological markers in blood but lacking clinical signs and symptoms of AD (typical or atypical phenotype), and D) olfactory abnormalities; (5) no traveling for 4 or more consecutive weeks during the study period; (6) willing to complete all study-related activities for 24 months and provide written informed consent.
Exclusion criteria
Exclusion criteria: (1) prior diagnosis or self-report of AD dementia and other dementia; (2) diagnosis or self-report of a major psychiatric illness (e.g., major depression, schizophrenia); (3) history of severe alcohol or drug abuse; (4) hearing or communication impairment, and other conditions that prevent cooperation; (5) a need to limit physical activity and/or diet due to functional decline, which included a history of chemotherapy for bone or joint disease, renal failure, ischemic heart disease, or cardiopulmonary disease, a diagnosed or self-reported neurodegenerative disease other than AD (e.g., Parkinson disease (PD) and PD-related diseases, Huntington's disease); (6) an inability to complete an MRI scan; (7) an inability to complete PET-CT; (8) an inability to perform a cognitive test; (9) currently participating in another clinical research trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| golbal cognition and cognitive domain scores; Ability of daily living; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of MCI and dementia and AD;Anxiety and depression scores ;Sleep status; Social engagement;Occurrence of frailty;Occurrence of cardiovascular disease;Human morphology index; Routine physical examination indicators ;Motor ability assessment;Health-related quality of life; | — |
Countries
China
Contacts
Public ContactGuirong Cheng
Wuhan University of Science and Technology
Outcome results
None listed