liver tumors
Conditions
Interventions
study group,group A:Abdominal compression and vacuum pad were used for body immobilization, followed by simulating CT scanning and 4D-MRI scanning.
No intervention is implemented for other radiothera
control group,group B:Conventional abdominal thermoplastic was used for immobilization (without abdominal compression), followed by simulating CT scans and 4D-MRI scans. The method of collecting image
Sponsors
Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age = 18; 2) ECOG 0-1; 3) Malignant tumors suitable for liver SBRT treatment, including primary hepatocellular carcinoma or liver metastasis; 4) The number of liver tumors = 5, and the diameter of a single tumor = 5cm; 5) Liver function is well reserved (Child-Pugh =B7)and sufficient normal liver tissue (= 700ml). 6) The research subjects fully understand the implementation of the study and voluntarily sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Poor liver function. i.e. Child-Pugh score is greater than 7 points; Or patients with ALT and AST = 2.5 times of the ULN, total bilirubin = 2 times the ULN, ALB = 29g/L; 2) Patients with tumors that are close to the intestines and other organs at risk, such as the stomach, esophagus, duodenum, and jejunum, and are difficult to tolerate SBRT radiation therapy; 3) Patients with residual liver volume<700ml and difficulty tolerating radiotherapy; 4) Individuals who are allergic to iodine contrast agents or gadolinium contrast agents; 5) Individuals with metal in their bodies or with claustrophobia who are unable to complete MRI scans; 6) Those who cannot understand the process of abdominal compression and cannot cooperate to complete the fixation of abdominal compression positions; 7) Pregnant women or patients who still have fertility requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cranial-caudal motion amplitude of liver; | — |
Secondary
| Measure | Time frame |
|---|---|
| anterior-posterior motion amplitude of liver;lateral motion amplitude of liver;Liver translocation between CBCT and simulating CT in cranial-caudal, anterior-posterior, lateral direction;tumor volume in simulating CT and MRI;objective response rate;local failure free survival;overall survival; | — |
Countries
China
Contacts
Public ContactHongzhi Wang
Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute
Outcome results
None listed