pneumonia
Conditions
Interventions
atomization group (inhale polymyxin B):NA
Non-atomized group:none
Sponsors
The first affiliated hospital, zhe jiang university
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The clinician suspects that the lung lesions are infectious or co-infected on the basis of the underlying disease, and there is a positive result of carbapenem-resistant microorganism culture. Specifically include: 1. The diagnosis meets the VAP or HAP criteria and has a positive CRO culture of respiratory secretions; 2. Use a vibrating mesh nebulizer to inhale antibiotics into patients; 3. Clinical use of antibacterial regimens containing polymyxin B nebulization treatment, the treatment course of nebulization inhalation is 3-14 days; 4. Subjects have informed consent, understand and are willing to cooperate with the trial protocol, and sign relevant documents.
Exclusion criteria
Exclusion criteria: 1. Patients who are diagnosed with VAP or HAP for the second time in the same hospitalization period and are treated with antibiotic nebulization; 2. Patients who are aerosolized with antifungal drugs; 3. In the middle of the study, patients or their family members request to stop antibiotic nebulization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbial removal;Microorganisms not cleared;30-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Outcome Evaluation - Improvement;Clinical Outcome Evaluation - Invalid;Evaluation of clinical outcome - unable to judge; | — |
Countries
China
Contacts
Public ContactHua Zhou
The first affiliated hospital, zhe jiang university
Outcome results
None listed