coronary heart disease with coronary artery bypass grafting
Conditions
Interventions
ERAS group:Usual care and ERAS.
pre CR-ERAS group:Usual care and pre CR-ERAS.
post CR-ERAS group:Usual care and post CR-ERAS.
peri CR-ERAS group:Usual care and peri CR-ERAS.
Sponsors
Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (i) aged 18 years or older; (ii) diagnosed with coronary heart disease through coronary angiogram and laboratory examination based on symptoms and signs of the patient; (iii) met indications of CABG with or without valvular surgery defined as at least 2 vessel lesions or significant left major coronary arteries stenosis or SYNTAX score = 33; (iv) with normal cognition and being able to cooperate with the CR training; (v) agreed to participate in the trial and signed the consent form.
Exclusion criteria
Exclusion criteria: (i) pregnant; (ii) undergoing aortic surgery or equivalent surgery within 6 months; (iii) history of cardiogenic shock or sudden cardiac arrest and severe hypertension; (iv) having complications with persistent ischemia, hemodynamic impairment, or at risk of arterial occlusion with massive myocardial infarction; (v) having complications with severe cardiac insufficiency (NYHA of IV or LVEF<35%) and malignant arrhythmias; (vi) having acute myocardial infarction complicated with severe mechanical complications such as ventricular aneurysm formation, mitral regurgitation caused by papillary muscle rupture, or rupture of free wall; (vii) having peripheral neuropathy, peripheral artery disease, superficial thrombophlebitis, deep vein thrombosis, and thus unable to tolerate rehabilitation training; (viii) terminal disease like cancer, malignancies, liver failure, or other severe systemic diseasess, (ix) participated in other trials within 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of post-operative cardiopulmonary complications occurring within the first 10 post-operative days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of post-operative pulmonary complications;Occurrence of post-operative cardiac complications;Occurrence of stroke;The occurrence of acute kidney injury;Delirium rate;Reintubation rate;The occurrence of revascularization;Early drainage tube removal rate;all-cause mortality;ICU readmission rate;Left ventricular ejection fraction (LVEF);metabolic equivalents (METs);the mechanical ventilation length;ICU Lenth of stay;Total lenth of stay;Total medical expenses; | — |
Countries
CHINA
Contacts
Public ContactYu Zheng
the First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed