Amyotrophic lateral sclerosis
Conditions
Interventions
Experimental group:Samples of blood, urine and stool were taken
Control group:Samples of blood, urine and stool were taken
Sponsors
Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. All ALS patients met the revised E1 Escorial diagnostic criteria for clinically confirmed or probable ALS; 2, understand the whole process of the test, voluntarily participate in and sign the informed consent, provided by or legally authorized representatives. Inclusion criteria for healthy controls ? Match gender, age, and ALS group patients; ? Understand the entire process of the experiment, voluntarily participate and sign an informed consent form, provided by a legally authorized representative.
Exclusion criteria
Exclusion criteria: 1, severe liver and kidney function damage (ALT, AST, TBiL, Cr more than 50% of the upper limit of normal); 2. Combined with malignant tumor, or history of malignant tumor; 3, complicated with cerebrovascular disease, Parkinson's disease, dementia, intracranial space and other neurological diseases; 4, suffering from diarrhea, diabetes, ulcerative colitis, intestinal stress syndrome, Crohn's disease or other infectious diseases; 5. Received chemotherapy, radiotherapy or surgery; 6, 3-6 months before the sampling, antibiotics, steroid hormones, Chinese herbs (including oral, intramuscular or intravenous injection) or probiotics (such as yogurt), etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALS Functional Rating Scale–Revised (ALSFRS-R) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| ALS Assessment Questionnaire score-40;Fatigue severity scale (FSS);The Hamilton anxiety scale (HAMA);The Hamilton depression scale, HAMD;Gut microbiome; | — |
Countries
China
Contacts
Public Contactlan danmei
Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)
Outcome results
None listed