chronic kidney disease
Conditions
Interventions
Group P:I: E=1:2, FiO2=50%, respiratory parameters were adjusted based on PETCO2 and PaCO2 and pH in arterial blood gas analysis. During surgery, PaCO2 was allowed to gradually rise to PaCO2 46-55 mmH
Group C:Tidal volume is 6-8 mL/kg, I: E=1:2, FiO2=50%, respiratory rate is 12-15 times/min, and PaCO2 is maintained at 35-45 mmHg
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients with CKD-5 stage undergoing peritoneal dialysis tube implantation under general anesthesia 2: Age =18 years old 3: BMI 16-28kg/m2 4: No surgical contraindications, conscious and independent thinking ability 5: No cognitive behavior disorder
Exclusion criteria
Exclusion criteria: 1: Refusing to sign the informed consent form 2: Suffering from severe coronary heart disease, stroke or other central nervous system diseases before operation 3: Patients with elevated ICP (such as traumatic intracranial hematoma and intracranial space-occupying lesions) 4: Previous mental illness or long-term use of psychotropic drugs 5: Severe visual or hearing impairment and unable to accept neuropsychological assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| residual renal function;Incidence of postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal blood flow index;Awakening index;Hemodynamics indicators;blood gas analysis; | — |
Countries
China
Contacts
Public ContactSun Zhentao
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed