diabetes mellitus
Conditions
Interventions
Group esketamine(Healthy patients):esketamine anesthesia induction
Group L-Sevoflurane(T2DM patients):Sevoflurane anesthesia induction
Group L-Sevoflurane(Healthy patients):Sevoflurane anesthesia induction
Group Propofol(T2DM patients):Propofol anesthesia induction
Group Propofol(Healthy patients):Propofol anesthesia induction
Group H-Sevoflurane(T2DM patients):Sevoflurane anesthesia induction
Group H-Sevoflurane(Healthy patients):Sevoflurane anesthesia induction
Group esketamine(T2DM patients):esketamine anesthesia induction
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-60 years old, ASA I-III grade, surgical patient under general anesthesia; (2) Previously healthy patients (glycated hemoglobin<5.7%, fasting blood glucose<6.1 mmol/L) or simply diagnosed as T2DM patients; (3) Smooth communication, willing to participate in this study, and willing to provide informed consent.
Exclusion criteria
Exclusion criteria: (1) ASA = Level III patients with severe illnesses, including indigestion, liver failure, renal failure, severe gallbladder and pancreatic diseases, stroke, malignant tumors, or unstable cardiovascular diseases (such as myocardial infarction, ketosis, or hyperthyroidism); (2) Patients taking glucocorticoids; And patients with fasting blood glucose>10 mmol/L, random or postprandial blood glucose = 12 mmol/L, or glycated hemoglobin>9% during the intervention period; (3) Serious visual and auditory barriers, language barriers, and/or communication difficulties that result in inability to communicate; (4) Patients with concomitant neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's disease, psychological disorders, alcohol dependence, and drug addiction; (5) Those who have used sedative drugs within a week, or those who have previously used sedative drugs for a long period of time (= 3 months); (6) Individuals with mental illness; (7) Preoperative cognitive impairment with MMSE scores lower than the corresponding educational threshold: illiteracy = 17 points, primary school (education = 6 years) = 20 points, secondary school or above (education>6 years) = 23 points; (8) The surgical time is less than 30 minutes, and the stable period of anesthesia cannot be identified; (9) Accidental discharge or refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of consciousness disappearance, postoperative agitation and postoperative pain scores of different anesthetics in healthy patients and diabetes patients were observed.; | — |
Secondary
| Measure | Time frame |
|---|---|
| To observe the changes of EEG (including EEG power, amplitude phase coupling, brain network analysis related indicators), analgesic drug use and blood biochemical indicators between non diabetes patients and diabetes patients with different anesthetics;;To observe the effect of different anesthetics on the dreams of non diabetes patients and diabetes patients; | — |
Countries
China
Contacts
Public ContactBin Han
Peking University Third Hospital
Outcome results
None listed