Osteoarthritis
Conditions
Interventions
Control group :None
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: All sexes, age >60 years, severe knee osteoarthritis with total knee replacement surgery, study diagnosis and surgical treatment criteria refer to: Chinese Medical Association Orthopaedic Branch "Guidelines for the diagnosis and treatment of osteoarthritis" (2018 edition), AAOS "Evidence-based medical guidelines for osteoarthritis of the knee (2013 second edition) Control group (normal cartilage): gender and age are not limited
Exclusion criteria
Exclusion criteria: 1, tumor, tuberculosis and other chronic wasting diseases; 2, gout, rheumatoid arthritis and other types of bone and joint diseases; 3, congenital factors caused by knee deformity and dysfunction; 4, suffering from psychiatric diseases can not cooperate with the study; 5, menstruating and pregnant women; 6, previous history of knee infection and surgical trauma; 7, previous history of joint cavity puncture and injection therapy; 8, history of hormone, immunosuppressant and other drugs; 9, serious systemic diseases and no significant abnormalities in liver, kidney function and electrolytes. Control group (normal cartilage): Patients with previous diagnosis of osteoarthritis, severely injured amputees with normal articular cartilage, severely injured first-stage joint replacement patients, and deceased donor patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| miR-30a;WNT2;Interleukin;TNF-a;MMPs; | — |
Secondary
| Measure | Time frame |
|---|---|
| COMP;YKL-40;CTX-?;ACAN;hsa_circ_0023404;miR-217;HIF-1a;VEGF;Bcl-2;collagen II;aggrecan;ADAMTS-4;ADAMTS-5;PCNA;CD14;ACTG1;HLA-DRA;COL6A3;Col6a1;Col1a1; | — |
Countries
China
Contacts
Public ContactLi Guangdi
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed