Osteoarthritis
Conditions
Interventions
Control group:None
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: Experimental group (pathological cartilage): All sexes, age >60 years, severe knee osteoarthritis with total knee replacement surgery, study diagnosis and surgical treatment criteria refer to: Chinese Medical Association Orthopaedic Branch "Guidelines for the diagnosis and treatment of osteoarthritis" (2018 edition), AAOS "Evidence-based medical guidelines for osteoarthritis of the knee (2013 second edition) Control group (normal cartilage): gender and age are not limited
Exclusion criteria
Exclusion criteria: 1. Chronic consumptive diseases such as tumors and tuberculosis; 2. Other types of bone and joint diseases such as gout and rheumatoid arthritis; 3. Congenital deformity and dysfunction of knee joint caused by congenital factors; 4. People with mental illness can't cooperate with researchers; 5. Menstrual and pregnancy women; 6. With a history of knee joint infection and surgical trauma; 7. With a history of articular cavity puncture and injection therapy; 8. With a history of drugs such as hormone free and immunosuppressive drugs; 9. With serious systemic diseases and no obvious abnormalities in liver, renal function and electrolytes. Control group (normal cartilage): Patients with previous diagnosis of osteoarthritis, severely injured amputees with normal articular cartilage, severely injured first-stage joint replacement patients, and deceased donor patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| circPVT1;miR-125b;Cbfß;Interleukin;TNF-a;MMPs;COMP; | — |
Secondary
| Measure | Time frame |
|---|---|
| YKL-40;CTX-?;ACAN;hsa_circ_0023404;HIF-1a;VEGF;Bcl-2;collagen II;aggrecan;ADAMTS-4;ADAMTS-5;PCNA;CD14;ACTG1;HLA-DRA;COL6A3;Col6a1;Col1a1; | — |
Countries
China
Contacts
Public ContactLi Guangdi
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed