Cerebrovascular disease
Conditions
Interventions
non hormone therapy group:oral aspirin tablets (100mg once a day), Clopidogrel (75mg once a day), Atorvastatin calcium tablets (20mg once a day)
Hormone therapy group:Oral administration of methylprednisolone tablets (4mg once per day) on the basis of the control group
Sponsors
Xi'an Fifth Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Comply with the diagnostic criteria for acute ischemic stroke proposed in the 2018 Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke; (2) Meets the diagnostic criteria for RA proposed by the American Rheumatology Society/European Alliance Against Rheumatology (ACR/EULAR) in 2010; (3) Acute cerebral infarction onset time = 7 days; (4) Head MRI examination confirmed the presence of cerebral infarction lesions; (5) Can cooperate with TCD inspection; (6) Color Doppler ultrasound of neck vessels indicates that Stenosis = 50%; (7) The patient or family member signs an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Existence of other rheumatic immune diseases; (2) Presence of cerebral hemorrhage, tumors, trauma, etc; (3) Severe liver and kidney dysfunction, cardiac insufficiency, abnormal coagulation mechanisms, gastrointestinal bleeding, and other diseases occur; (4) The medication needs to be adjusted due to intolerance to methylprednisolone tablets or changes in the condition; (5) Failure to adhere to medication or cooperate with follow-up work.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurological function assessment;Hemodynamic evaluation;Inflammatory activity indicators of rheumatoid arthritis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rheumatoid arthritis related inflammatory factors; | — |
Countries
China
Contacts
Public ContactYan Jun
Xi'an Fifth Hospital
Outcome results
None listed