Postoperative depression
Conditions
Interventions
experimental group :Eesketamine + Sufentanil PCIA group (Group E, n=60, esketamine 1.0 mg / kg and sufentanil 2.0 µ g / kg)
control group:Sufentanil PCIA group (Group C, n=60, sufentanil 2.0 µ g / kg)
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
35 Years to 64 Years
Inclusion criteria
Inclusion criteria: ? Sex is not limited, age 35~64 years, body mass index (BMI) 19~27 kg m-2. ? colonoscopy biopsy and surgical pathology confirmed the initial diagnosis of colorectal cancer, which met the relevant diagnostic criteria of The Chinese Standards for Diagnosis and Treatment of Colorectal Cancer (2020 edition).? Elective laparoscopic radical treatment of colorectal cancer, meet the surgical indications; ? HAMD score <7 points; ? ASA grade ?~ ?; ? cardiac function grade ?~?, important organ function without obvious abnormality; ? know and agree to the study content.
Exclusion criteria
Exclusion criteria: ? Open or conversion to laparotomy surgery; ? HAMD score> 7; ? with infectious diseases, blood disease, immune system disease, abnormal coagulation function and severe infected persons; ? other cancer; serious ? other organs; ? mental illness, preoperative cognitive dysfunction; ? for nearly 1 month; ? contraindications of narcotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD grade;VAS grade;Postoperative adverse effects;Brain-derived neurotrophic factor(BDNF); | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay Score;Serum inflammatory cytokines IL-6,TNF-a,IL-10; | — |
Countries
China
Contacts
Public ContactZhihua Sun
Xiangya Hospital of Central South University
Outcome results
None listed