lung injury
Conditions
Interventions
Control group:Total intravenous general anesthesia
experimental group:Total intravenous general anesthesia added dexmedetomidine
Sponsors
the Third Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Emergency patients undergoing amputated finger replantation; (2) Age =16 years old, male or female; (3) American Society of Anesthesiologists (ASA) grade ?~?
Exclusion criteria
Exclusion criteria: (1) allergic to dexmedetomidine or its drug components; (2) severe heart block or severe ventricular dysfunction; (3) patients during pregnancy or lactation; (4) who underwent autogenous vascular transplantation due to the absence or necrosis of intrinsic vessels caused by crush or avulsion injury; (5) who did not agree to general anesthesia; (6) cognitive impairment or inability to communicate effectively; (7) who were deemed unsuitable for the trial by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative lung injury;Oxygenation index, pH, partial pressure of oxygen, partial pressure of carbon dioxide,SOD, MDA, CRP, Tnf-a, IL-1ß and IL-6 at T0-T2 and on the first day after surgery (T3); | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs were recorded 5min before induction of anesthesia (T0), 5min after induction of anesthesia (T1), and at the end of surgery (T2);The operation time;tourniquet use time;intraoperative fluid infusion volume;intraoperative urine volume;Adverse events during hospitalization; | — |
Countries
China
Contacts
Public ContactLu Kejian
the Third Affiliated Hospital of Guangxi Medical University
Outcome results
None listed