coronary artery disease
Conditions
Interventions
group with high immature platelet fraction(IPF):None
group with low IPF:None
Sponsors
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 80 years old, men or women; 2.Patients with coronary artery disease diagnosed by coronary angiography with diameter stenosis = 50% in at least one coronary artery. 3.Undergoing antiplatelet therapy with aspirin, or P2Y12 receptor antagonist such as clopidogrel or ticagrelor, or dual-antiplatelet therapy: aspirin+ clopidogrel or ticagrelor;
Exclusion criteria
Exclusion criteria: 1.Intolerance or allergy to aspirin, clopidogrel or ticagrelor; 2.Long-term concomitant need for oral anticoagulants, glucocorticoids or non-steroidal anti-inflammatory drugs; 3. Severe hematological disorders,such as disorders in platelet production and functions, hemoglobin < 90g/L or coagulation disorders, etc.; 4.Active bleeding or severe bleeding event within 3 months (BARC=2); 5.Blood transfusion within 30 days; 6.Other severe diseases, such as severe liver insufficiency (Child Pugh B or C), chronic renal insufficiency requiring dialysis, serious infection or malignant neoplastic diseases, etc; 7.Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of major adverse cardiovascular event (MACE); | — |
Secondary
| Measure | Time frame |
|---|---|
| the incidence of bleeding event (BARC=2);the all-cause mortality; | — |
Countries
China
Contacts
Public ContactRuqiong Nie
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Outcome results
None listed